Inspired by @tv 's list about "roles of a lifetime." These are, perhaps,going to be more popular than an award winning role.
  1. Mike Myers: Wayne, Austin Powers, Dr. Evil, Shrek
  2. Harrison Ford:Han Solo, Indiana Jones, Jack Ryan, and Dr. Richard Kimble
  3. Tom Cruise: Joel, Maverick, Ethan Hunt, Jerry McGuire
  4. Kevin Costner: Ray Kinsella, Eliot Ness, Crash Davis, Frank Farmer
  5. Johnny Depp: Captain Jack Sparrow, Sweeney Todd, Willy Wonka
  6. Gene Wilder:Dr.Frankenstein and Willy Wonka
  7. Debbie Reynolds: Cathy Selden and the Unsinkable Molly Brown
  8. Susan Sarandon: Janet and Louise
  9. Julia Roberts: Vivian Ward, Anna Scott, and Erin Brockovich
  10. Meryl Streep: Karen Silkwood, Sophie, Margaret Thatcher, Julia Child, and on and on
  11. Julie Andrews: Mary Poppins and Maria Von Trapp
  12. Whoopi Goldberg: Celie, Deloris, and Oda Mae Brown
  13. Danny Glover: Mister and Roger Murtaugh
  14. Eddie Murphy: Axel Foley, Donkey, Billy Ray Valentine, the Klumps, Prince Akeem
  15. Gary Oldman
    Sid Vicious, Dracula, Sirius Black
    Suggested by   @emtwids
  16. Adam Sandler
    Billy Madison, Happy Gilmore, Bobby Boucher, etc etc etc
    Suggested by   @emtwids
  17. Dick van Dyke: Albert F. Peterson, Bert, Rob Petrie, Dr. Mark Sloan
    Bye Bye Birdie, Mary Poppins, The Dick can Dyke Show, Diagnosis Murder
    Suggested by   @laneeeee_sue
  18. I may have a crush on him.
    Four Christmasas, Wedding Crashers, Couples Retreat
    Suggested by   @cvlop61