Inspired by @tv 's list about "roles of a lifetime." These are, perhaps,going to be more popular than an award winning role.
  1. Mike Myers: Wayne, Austin Powers, Dr. Evil, Shrek
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  2. Harrison Ford:Han Solo, Indiana Jones, Jack Ryan, and Dr. Richard Kimble
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  3. Tom Cruise: Joel, Maverick, Ethan Hunt, Jerry McGuire
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  4. Kevin Costner: Ray Kinsella, Eliot Ness, Crash Davis, Frank Farmer
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  5. Johnny Depp: Captain Jack Sparrow, Sweeney Todd, Willy Wonka
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  6. Gene Wilder:Dr.Frankenstein and Willy Wonka
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  7. Debbie Reynolds: Cathy Selden and the Unsinkable Molly Brown
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  8. Susan Sarandon: Janet and Louise
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  9. Julia Roberts: Vivian Ward, Anna Scott, and Erin Brockovich
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  10. Meryl Streep: Karen Silkwood, Sophie, Margaret Thatcher, Julia Child, and on and on
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  11. Julie Andrews: Mary Poppins and Maria Von Trapp
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  12. Whoopi Goldberg: Celie, Deloris, and Oda Mae Brown
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  13. Danny Glover: Mister and Roger Murtaugh
    Giphy downsized medium
  14. Eddie Murphy: Axel Foley, Donkey, Billy Ray Valentine, the Klumps, Prince Akeem
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  15. Gary Oldman
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    Sid Vicious, Dracula, Sirius Black
    Suggested by @emtwids
  16. Adam Sandler
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    Billy Madison, Happy Gilmore, Bobby Boucher, etc etc etc
    Suggested by @emtwids
  17. Dick van Dyke: Albert F. Peterson, Bert, Rob Petrie, Dr. Mark Sloan
    Static
    Bye Bye Birdie, Mary Poppins, The Dick can Dyke Show, Diagnosis Murder
    Suggested by @laneeeee_sue
  18. Giphy
    I may have a crush on him.
  19. VINCE VAUGHN
    Local
    Four Christmasas, Wedding Crashers, Couples Retreat
    Suggested by @cvlop61