These are roles that define an actor and cement their pop-culture royalty status.
  1. Julia Louis-Dreyfus
    Seinfeld and Veep
  2. Bryan Cranston
    Malcolm in the Middle and Breaking Bad
  3. Ed O'Neill
    Married with Children and Modern Family
  4. Rob Lowe
    The West Wing and Parks and Rec
  5. Jeffrey Tambor
    Arrested Development and Transparent
  6. Neil Patrick Harris
    Doogie Howser, M.D., and How I Met Your Mother
    Suggested by   @franksars
  7. I'm gonna kill this list by adding Ted McGinley.
    How do you even spell it?
    Suggested by   @jaidub
  8. Lauren Graham
    Parenthood and Gilmore Girls
    Suggested by   @lisafischer
  9. Courtney Cox for Friends and Cougar Town.
    Suggested by   @RichardGoodman
  10. Adam Scott for Party Down and Parks And Rec
    Suggested by   @RichardGoodman
  11. Kristen Bell for Veronica Mars and House Of Lies
    Suggested by   @RichardGoodman
  12. Julianna Margulies
    ER and The Good Wife
    Suggested by   @nervesofscared
  13. Katey Sagal
    Married With Children and Sons of Anarchy
    Suggested by   @nervesofscared
  14. Edie Falco
    The Sopranos and Nurse Jackie
    Suggested by   @nervesofscared
  15. Laura Prepon
    That 70s Show, Orange is the New Black
    Suggested by   @francium
  16. Betty White
    The Mary Tyler Moore Show, The Golden Girls, Hot in Cleveland.
    Suggested by   @kiraandlulu
  17. Bea Arthur
    Maude and The Golden Girls
    Suggested by   @kiraandlulu
  18. Amy Poehler for SNL and Parks and Rec
    Suggested by   @minabird
  19. Johnny galecki for Roseanne and Big Bang theory
    Suggested by   @cakecaroline
  20. Jeff Garlin.
    From Curb Your Enthusiasm to The Goldbergs,
    Suggested by   @MichaelDeMarco
  21. Mary Tyler Moore
    The Dick Van Dyke Show and The Mary Tyler Moore Show
    Suggested by   @moonjockey
  22. Claire Danes for My So Called Life and Homeland
    Suggested by   @lorimcs
  23. Keri Russell for Felicity and The Americans
    Suggested by   @lorimcs
  24. Idris Elba
    The Wire and Luther
    Suggested by   @MacDaddy
  25. Georgie Parker - A Country Practice & All Saints
    Suggested by   @goodwinthom
  26. Calista Flockhart
    Ally McBeal and Brothers & Sisters
    Suggested by   @DawnCloud
  27. Ryan Kwanten - Home and Away and True Blood
    Suggested by   @spphawke
  28. Jane Krakowski
    30 Rock & Unbreakable Kimmy Schmidt (also Ally McBeal)
    Suggested by   @DawnCloud
  29. Michael C. Hall - Dexter & 6 Feet Under
    Suggested by   @tadreese
  30. Thomas Gibson
    Dharma and Greg & Criminal Minds
    Suggested by   @alanarogerrrrs
  31. Michael Kenneth Williams
    Omar Little (The Wire) & Chalk White (Boardwalk Empire)
    Suggested by   @tadreese
  32. Tina Fey for SNL and 30 Rock!
    Suggested by   @fuggirls
  33. Peter Capaldi - The Thick of It and Doctor Who
    Suggested by   @ejpevents
  34. Connie Britton
    Friday Night Lights and Nashville
    Suggested by   @graceofwrath
  35. John Francis Daley
    Freaks and Geeks and Bones
    Suggested by   @car_lay96
  36. Joshua Jackson
    Dawson's Creek and Fringe
    Suggested by   @wilmotwrites
  37. Mayim Bialik
    Blossom and The Big Bang Theory
    Suggested by   @wilmotwrites
  38. Jason Segel - Freaks and Geeks and How I met your Mother
    Suggested by   @robynnestarr
  39. Melissa McCarthy
    Gilmore Girls, Mike and Molly plus all of her movies
    Suggested by   @steph11
  40. Lisa Kudrow
    Friends and The Comeback
    Suggested by   @emtwids
  41. Adam Pally
    Max Blum and Peter Prentice.
    Suggested by   @Boogie
  42. Matt LeBlanc
    That little NBC show about 6 friends in New York. I forget the name. And Episodes!
    Suggested by   @Boogie
  43. Rashida Jones (when have I not suggested her?)
    Karen Fillipelli, Ann Perkins, Angie Tribeca, and the Freak from Freaks and Geeks.
    Suggested by   @Boogie
  44. Mindy Kaling
    The Office & The Mindy Project
    Suggested by   @rachelanne
  45. Ben McKenzie
    The OC, Southland, & Gotham
    Suggested by   @sarahmccoy
  46. Kelsey Grammer
    Cheers & Frasier
    Suggested by   @kiraandlulu
  47. Sophia Bush
    One Tree Hill & Chicago PD
    Suggested by   @sarahmccoy
  48. Alia Shawkat
    Arrested Development & Search Party
    Suggested by   @sarahmccoy
  49. I'd add The Simpsons for Kelsey too. And Lara Flynn Boyle for Twin Peaks and The Practice.
    Suggested by   @rycores
  50. David Boreanaz
    Buffy/Angel & Bones
    Suggested by   @sarahmccoy
  51. David Duchovny
    The X Files and Californication
    Suggested by   @okayerin
  52. Christina Applegate
    Married... With Children and Samantha Who and Up All Night
    Suggested by   @theranman
  53. Jean Smart
    Designing Women and 24 and Samantha Who and Fargo
    Suggested by   @theranman
  54. Don Knotts-Barney and Mr. Furley
    Suggested by   @MaddyandOwensMom
  55. Lark Voorhies
    Saved by the Bell and Days of Our Lives
    Suggested by   @theranman
  56. Angela Kinsey-The Office, Hot Wives of Orlando/Las Vegas, and Haters Back Off.
    Suggested by   @MaddyandOwensMom
  57. Aziz Ansari
    Parks and Recreation and Master of None
    Suggested by   @theranman
  58. Ellie Kemper-The Office and Kimmy Schmidt
    Suggested by   @MaddyandOwensMom
  59. Peter Krause-Sports Night, Six Feet Under, Parenthood
    Suggested by   @MaddyandOwensMom
  60. Sherman Hemsley
    The Jeffersons and Amen
    Suggested by   @theranman
  61. Joshua Malina
    Sports Night, The West Wing and Scandal
    Suggested by   @brimattia
  62. Craig T. Nelson
    Coach and Parenthood
    Suggested by   @theranman
  63. Michael J. Fox
    Family Ties and Spin City
    Suggested by   @brimattia
  64. Ray Romano
    Everybody Loves Raymond and Parenthood
    Suggested by   @theranman
  65. Larry Hagman
    I Dream of Jeannie and Dallas
    Suggested by   @brimattia
  66. Jared Paladecki
    Gilmore Girls and Supernatural
    Suggested by   @theranman
  67. Ron Howard
    The Andy Griffith Show and Happy Days
    Suggested by   @brimattia
  68. Mark Harmon
    St. Elsewhere, The West Wing and NCIS.
    Suggested by   @brimattia
  69. Willow AND Lily anyone !!??
    Also this one time at summer camp + I heard she has a new pilot so she'll be amazing again
    Suggested by   @Lisa_Fav
  70. Fred Armisen
    SNL, Portlandia, Documentary Now!
    Suggested by   @okayerin
  71. Melissa Joan Hart
    Clarissa Explains It All and Sabrina the Teenage Witch
    Suggested by   @amieshmamie
  72. Ted Danson
    Ted was into TV when TV wasn't cool: Cheers, Becker, Bored to Death, the cameos in Curb Your Enthusiasm (!), Damages, Fargo, and don't forget CSI
    Suggested by   @marykathryn
  73. Ok one more! Danny DeVito-Taxi and It's Always Sunny....
    Suggested by   @MaddyandOwensMom
  74. Ok maybe one more after that! Tony Danza-Taxi and Whose the Boss (shout-out to Judith Light-Karen and Angela!)
    Suggested by   @MaddyandOwensMom
  75. William Shatner
    Star Trek and TJ Hooker
    Suggested by   @julieann718
  76. Willie Garson
    Sex and the City and White Collar
    Suggested by   @solena
  77. Sterling K Brown
    People vs OJ, Army Wives, This is Us
    Suggested by   @Boogie
  78. Maura Tierney
    E.R. and The Affair
    Suggested by   @victralala
  79. Michael Emerson for Lost and Persons of Interest.
    Suggested by   @videodrew
  80. Will Arnett: Arrested Development and Bojack Horseman.
    Suggested by   @videodrew
  81. David Hasselhoff
    Knight Rider & Baywatch
    Suggested by   @_leia_
  82. Alec Baldwin
    Beetlejuice, 30 Rock, Donald Trump on SNL
    Suggested by   @isabana49
  83. Emilie de Ravin
    LOST (Claire) and Once Upon Time (Belle) ;)
    Suggested by   @adshurt