These are roles that define an actor and cement their pop-culture royalty status.
  1. Julia Louis-Dreyfus
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    Seinfeld and Veep
  2. Bryan Cranston
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    Malcolm in the Middle and Breaking Bad
  3. Ed O'Neill
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    Married with Children and Modern Family
  4. Rob Lowe
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    The West Wing and Parks and Rec
  5. Jeffrey Tambor
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    Arrested Development and Transparent
  6. Neil Patrick Harris
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    Doogie Howser, M.D., and How I Met Your Mother
    Suggested by @franksars
  7. I'm gonna kill this list by adding Ted McGinley.
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    How do you even spell it?
    Suggested by @jaidub
  8. Lauren Graham
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    Parenthood and Gilmore Girls
    Suggested by @lisafischer
  9. Courtney Cox for Friends and Cougar Town.
    Suggested by @RichardGoodman
  10. Adam Scott for Party Down and Parks And Rec
    Suggested by @RichardGoodman
  11. Kristen Bell for Veronica Mars and House Of Lies
    Suggested by @RichardGoodman
  12. Julianna Margulies
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    ER and The Good Wife
    Suggested by @nervesofscared
  13. Katey Sagal
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    Married With Children and Sons of Anarchy
    Suggested by @nervesofscared
  14. Edie Falco
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    The Sopranos and Nurse Jackie
    Suggested by @nervesofscared
  15. Laura Prepon
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    That 70s Show, Orange is the New Black
    Suggested by @francium
  16. Betty White
    The Mary Tyler Moore Show, The Golden Girls, Hot in Cleveland.
    Suggested by @kiraandlulu
  17. Bea Arthur
    Maude and The Golden Girls
    Suggested by @kiraandlulu
  18. Amy Poehler for SNL and Parks and Rec
    Suggested by @minabird
  19. Johnny galecki for Roseanne and Big Bang theory
    Suggested by @cakecaroline
  20. Jeff Garlin.
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    From Curb Your Enthusiasm to The Goldbergs,
    Suggested by @MichaelDeMarco
  21. Mary Tyler Moore
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    The Dick Van Dyke Show and The Mary Tyler Moore Show
    Suggested by @moonjockey
  22. Claire Danes for My So Called Life and Homeland
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    Suggested by @lorimcs
  23. Keri Russell for Felicity and The Americans
    Suggested by @lorimcs
  24. Idris Elba
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    The Wire and Luther
    Suggested by @MacDaddy
  25. Georgie Parker - A Country Practice & All Saints
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    Suggested by @goodwinthom
  26. Calista Flockhart
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    Ally McBeal and Brothers & Sisters
    Suggested by @DawnCloud
  27. Ryan Kwanten - Home and Away and True Blood
    Suggested by @spphawke
  28. Jane Krakowski
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    30 Rock & Unbreakable Kimmy Schmidt (also Ally McBeal)
    Suggested by @DawnCloud
  29. Michael C. Hall - Dexter & 6 Feet Under
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    Suggested by @tadreese
  30. Thomas Gibson
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    Dharma and Greg & Criminal Minds
    Suggested by @alanarogerrrrs
  31. Michael Kenneth Williams
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    Omar Little (The Wire) & Chalk White (Boardwalk Empire)
    Suggested by @tadreese
  32. Tina Fey for SNL and 30 Rock!
    Suggested by @fuggirls
  33. Peter Capaldi - The Thick of It and Doctor Who
    Suggested by @ejpevents
  34. Connie Britton
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    Friday Night Lights and Nashville
    Suggested by @graceofwrath
  35. John Francis Daley
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    Freaks and Geeks and Bones
    Suggested by @car_lay96
  36. Joshua Jackson
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    Dawson's Creek and Fringe
    Suggested by @wilmotwrites
  37. Mayim Bialik
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    Blossom and The Big Bang Theory
    Suggested by @wilmotwrites
  38. Jason Segel - Freaks and Geeks and How I met your Mother
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    Suggested by @robynnestarr
  39. Lisa Kudrow
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    Friends and The Comeback
    Suggested by @emtwids
  40. Adam Pally
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    Max Blum and Peter Prentice.
    Suggested by @Boogie
  41. Matt LeBlanc
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    That little NBC show about 6 friends in New York. I forget the name. And Episodes!
    Suggested by @Boogie
  42. Rashida Jones (when have I not suggested her?)
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    Karen Fillipelli, Ann Perkins, Angie Tribeca, and the Freak from Freaks and Geeks.
    Suggested by @Boogie
  43. Mindy Kaling
    Static
    The Office & The Mindy Project
    Suggested by @rachelanne
  44. Ben McKenzie
    Static
    The OC, Southland, & Gotham
    Suggested by @sarahmccoy
  45. Kelsey Grammer
    Cheers & Frasier
    Suggested by @kiraandlulu
  46. Sophia Bush
    Static
    One Tree Hill & Chicago PD
    Suggested by @sarahmccoy
  47. Alia Shawkat
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    Arrested Development & Search Party
    Suggested by @sarahmccoy
  48. I'd add The Simpsons for Kelsey too. And Lara Flynn Boyle for Twin Peaks and The Practice.
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    Suggested by @rycores
  49. David Boreanaz
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    Buffy/Angel & Bones
    Suggested by @sarahmccoy
  50. David Duchovny
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    The X Files and Californication
    Suggested by @okayerin
  51. Christina Applegate
    Static
    Married... With Children and Samantha Who and Up All Night
    Suggested by @theranman
  52. Jean Smart
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    Designing Women and 24 and Samantha Who and Fargo
    Suggested by @theranman
  53. Don Knotts-Barney and Mr. Furley
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    Suggested by @MaddyandOwensMom
  54. Lark Voorhies
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    Saved by the Bell and Days of Our Lives
    Suggested by @theranman
  55. Angela Kinsey-The Office, Hot Wives of Orlando/Las Vegas, and Haters Back Off.
    Giphy
    Suggested by @MaddyandOwensMom
  56. Aziz Ansari
    Static
    Parks and Recreation and Master of None
    Suggested by @theranman
  57. Ellie Kemper-The Office and Kimmy Schmidt
    Static
    Suggested by @MaddyandOwensMom
  58. Peter Krause-Sports Night, Six Feet Under, Parenthood
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    Suggested by @MaddyandOwensMom
  59. Sherman Hemsley
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    The Jeffersons and Amen
    Suggested by @theranman
  60. Joshua Malina
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    Sports Night, The West Wing and Scandal
    Suggested by @brimattia
  61. Craig T. Nelson
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    Coach and Parenthood
    Suggested by @theranman
  62. Michael J. Fox
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    Family Ties and Spin City
    Suggested by @brimattia
  63. Ray Romano
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    Everybody Loves Raymond and Parenthood
    Suggested by @theranman
  64. Larry Hagman
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    I Dream of Jeannie and Dallas
    Suggested by @brimattia
  65. Jared Paladecki
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    Gilmore Girls and Supernatural
    Suggested by @theranman
  66. Ron Howard
    Static
    The Andy Griffith Show and Happy Days
    Suggested by @brimattia
  67. Mark Harmon
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    St. Elsewhere, The West Wing and NCIS.
    Suggested by @brimattia
  68. Willow AND Lily anyone !!??
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    Also this one time at summer camp + I heard she has a new pilot so she'll be amazing again
    Suggested by @Lisa_Fav
  69. Fred Armisen
    Static
    SNL, Portlandia, Documentary Now!
    Suggested by @okayerin
  70. Melissa Joan Hart
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    Clarissa Explains It All and Sabrina the Teenage Witch
    Suggested by @amieshmamie
  71. Ted Danson
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    Ted was into TV when TV wasn't cool: Cheers, Becker, Bored to Death, the cameos in Curb Your Enthusiasm (!), Damages, Fargo, and don't forget CSI
    Suggested by @marykathryn
  72. Ok one more! Danny DeVito-Taxi and It's Always Sunny....
    Static
    Suggested by @MaddyandOwensMom
  73. Ok maybe one more after that! Tony Danza-Taxi and Whose the Boss (shout-out to Judith Light-Karen and Angela!)
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    Suggested by @MaddyandOwensMom
  74. William Shatner
    Static
    Star Trek and TJ Hooker
    Suggested by @julieann718
  75. Willie Garson
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    Sex and the City and White Collar
    Suggested by @solena
  76. Sterling K Brown
    Static
    People vs OJ, Army Wives, This is Us
    Suggested by @Boogie
  77. Maura Tierney
    Static
    E.R. and The Affair
    Suggested by @victralala
  78. Michael Emerson for Lost and Persons of Interest.
    Static
    Suggested by @videodrew
  79. Will Arnett: Arrested Development and Bojack Horseman.
    Static
    Suggested by @videodrew
  80. David Hasselhoff
    Static
    Knight Rider & Baywatch
    Suggested by @_leia_
  81. Alec Baldwin
    Giphy
    Beetlejuice, 30 Rock, Donald Trump on SNL
    Suggested by @isabana49
  82. Emilie de Ravin
    Static
    LOST (Claire) and Once Upon Time (Belle) ;)
    Suggested by @adshurt