Just a quick list off the top of my head.
  1. John Cena in Trainwreck
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    The inspiration for this list. I want a whole spinoff movie based on his character. He was such a good sport.
  2. Melissa McCarthy in Bridesmaids
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    I dragged my husband to see this movie because he thought it was going to be a chick flick. He was howling at the bathroom scene.
  3. Zach Galifianakis in The Hangover
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    Perhaps his break out role. There is a lot of creepy stuff going on in his head, and I love it.
  4. Leslie Mann in The 40-year-old Virgin
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    She is so effortlessly funny and awkward.
  5. Chris Tucker in The Fifth Element
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    He was mesmerizing. I also just love this movie so much.
  6. Jennifer Coolidge (AND Jane Lynch) in Best In Show
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    Even though it was an ensemble cast, these ladies killed it. And oh so quotable! Saying "it was a shitbox" to describe anything subpar is supremely satisfying.
    Suggested by @ameliaville
  7. Alfred in Batman vs Superman
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    Martha Wayne did too because Lauren Cohan but
    Suggested by @destiel
  8. Philip Seymour Hoffman in Along Came Polly
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    "I sharted."
    Suggested by @MatthewAlmont
  9. Megan Fox in This Is 40
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    Who knew back then she could be funny??
    Suggested by @Nikki
  10. Annie Potts in Pretty In Pink
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    Suggested by @lorimcs
  11. Woody Harrelson & Patricia Clarkson both in "Friends With Benefits"
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    Suggested by @kate81