Just a quick list off the top of my head.
  1. John Cena in Trainwreck
    The inspiration for this list. I want a whole spinoff movie based on his character. He was such a good sport.
  2. Melissa McCarthy in Bridesmaids
    I dragged my husband to see this movie because he thought it was going to be a chick flick. He was howling at the bathroom scene.
  3. Zach Galifianakis in The Hangover
    Perhaps his break out role. There is a lot of creepy stuff going on in his head, and I love it.
  4. Leslie Mann in The 40-year-old Virgin
    She is so effortlessly funny and awkward.
  5. Chris Tucker in The Fifth Element
    He was mesmerizing. I also just love this movie so much.
  6. Jennifer Coolidge (AND Jane Lynch) in Best In Show
    Even though it was an ensemble cast, these ladies killed it. And oh so quotable! Saying "it was a shitbox" to describe anything subpar is supremely satisfying.
    Suggested by @ameliaville
  7. Alfred in Batman vs Superman
    Martha Wayne did too because Lauren Cohan but
    Suggested by @destiel
  8. Philip Seymour Hoffman in Along Came Polly
    "I sharted."
    Suggested by @MatthewAlmont
  9. Megan Fox in This Is 40
    Who knew back then she could be funny??
    Suggested by @Nikki
  10. Annie Potts in Pretty In Pink
    Suggested by @lorimcs
  11. Woody Harrelson & Patricia Clarkson both in "Friends With Benefits"
    Suggested by @kate81