For 40 Years, No One Knew This Woman Discovered a Malaria Cure. Now She's Won a Nobel.
Tu Youyou became one of three scientists to win this year's Nobel Prize for medicine for her discovery of what has become a standard antimalarial treatment, artemisinin. But, remarkably, the public had no idea about Tu's lifesaving achievement until just four years ago. Full story: http://bit.ly/1WNpWLE
- •In 1967, Chairman Mao Zedong set up a secret mission ("Project 523") to find a cure for malaria. Hundreds of communist soldiers, fighting in the mosquito-infested jungles of Vietnam, were falling ill from malaria, and the disease was also killing thousands in southern China.Tu shared the 2015 prize for medicine with two other scientists who worked on parasitic diseases. Image credit: Xinhua News Agency.
- •Chinese scientists were initially unable to use synthetic chemicals to treat the mosquito-borne disease. Tu, a researcher at the Academy of Traditional Chinese Medicine in Beijing, had studied both Chinese and Western medicine, according to a New Scientist profile, and was hand-picked to search for an herbal cure.
- •"By the time I started my search [in 1969] over 240,000 compounds had been screened in the US and China without any positive results," she told New Scientist. But, she added: "The work was the top priority, so I was certainly willing to sacrifice my personal life."
- •Along with three assistants, she reviewed thousands of traditional Chinese remedies, testing them in mice. One compound — from the leaves of the Chinese wormwood plant, Artemisia annua, seemed to vanquish malaria parasites in the blood. But they didn't find their fix just yet.
- •The New Scientist reports: "Tu realised that their method of preparation, boiling up the wormwood, might have damaged the active ingredient. So she made another preparation using an ether solvent, which boils at 35 °C. When tested on mice and monkeys, it proved 100 per cent effective. "We had just cured drug-resistant malaria," Tu says.
- •Tu then had to test the treatment in humans — and tried it on herself first to make sure it was safe. After enduring no side effects, she organized clinical trials for people with malaria, and the participants were cleared of the disease within little more than a day.
- •Tu's discovery remains the fastest acting antimalarial, and artemisinin-based combination therapies are recommended by the World Health Organization as the first-line treatment for uncomplicated malaria.
- •For years, Tu's role in unlocking artemisinin was shrouded in secret — until researchers at the National Institutes of Health looked into the drug’s history and realized that Tu deserved credit for her work. In 2011, when she won the prestigious Lasker prize for medical research, the Chinese Communist Party moved to preserve her childhood home.
- •In a statement, Tu called artemisinin "a gift for the world’s people from traditional Chinese medicine," and urged researchers to turn to herbs in the search for cures for infectious diseases.