Inspired by @bjnovak !! I also decided to include the best/funniest line from each of these
  1. Airplane
    "We have to get this woman to a hospital" / "A hospital, what is it?" / "It's a big building with lots of sick people but that's not important right now!"
  2. Dumb and Dumber
    "We've got no food, we've got no jobs, our pets' hEADS ARE FALLING OFF!!"
  3. Mrs. Doubtfire
    "It was the drink that killed him" / "He was an alcoholic?" / "Oh, no. He was hit by a Guinness truck."
  4. Ferris Bueller's Day Off
    "Oh, he's very popular, Ed. The sportos, the motorheads, geeks, sluts, bloods, wasteoids, dweebies, dickheads, they all adore him. They think he's a righteous dude."
  5. Liar Liar
    "If I keep making this face, will it get stuck that way?" / "No. In fact, some people make a good living that way."
  6. Mean Girls
    "Do you guys need anything? Some snacks? A condom?"
  7. National Lampoon's Christmas Vacation
    "Every time Catherine would run the microwave I'd piss my pants and forget who I was for half an hour."
  8. School of Rock
    "Would you tell Picasso to sell one of his guitars?"
  9. The Princess Bride
    "True love is the greatest thing in the world. Except for a nice MLT, you know, a Mutton Lettuce Tomato Sandwich. When the Mutton is nice and lean....so perky. I love it."
  10. When Harry Met Sally
    "I'll have what she's having."