I don't really have any enemies, but still. Here, I'll get us started:
  1. Microsoft Word crashing, deleting a paper a mere two hours before the deadline.
  2. An eating disorder
  3. Having their parents divorce
  4. Losing 1 of your favorite earrings, but you still have the other one, so it mocks you.
  5. Failing their driving test three times
    #beenthere #donethat
  6. Getting stood up
  7. Having everyone forget their birthday
  8. Losing a precious photograph or momento
  9. Getting arthritis at 21
    Not the end of the world, but it really effects your ability to do the exploring and fun things 21 year olds are supposed to be doing
    Suggested by @libby92