To be fair, some of this may be from post-Sorkin West Wing but I DON'T CARE. Giving Sorkin credit for everything.
  1. "You're doing a big thing badly."
  2. "Decisions are made by those who show up."
  3. "Set fire to the room. Do it now."
  4. "Joshua, Josh, Josh"
  5. "It seems to me that more and more we've come to expect less from each other, and I think that should change."
  6. "I'm a registered Republican, I only seem liberal because I believe that hurricanes are caused by high barometric pressure and not gay marriage"
  7. "She's a person; the doctor pronounces her dead, not the news."
  8. "The real problem with all drugs is that they work. Fantastically. They're gear, right up until the moment they kill you."
  9. "There's literally no one in the world that I don't hate right now."
  10. "This guy's walking down the street when he falls into a hole. The walls are so steep he can't get out. A doctor passes by and the guy shouts up, 'Hey you! Can you help me out?' The doctor writes a prescription, throws it down in the hole, and moves on. Then a priest comes along and the guy shouts up, 'Father, I'm down in this hole...
  11. ...can you help me out?' The priest writes out a prayer, throws it down in the hole and moves on. Then a friend walks by. 'Hey, Joe, it's me. Can you help me out?' And the friend jumps in the hole. Our guy says, 'Are ya stupid? Now we're both down here.' The friend says, 'Yeah, but I've been down here before and I know the way out.'"
  12. "You really want to tempt the wrath of the whatever from high atop the thing?"
  13. "We came out of the cave, and we looked over the hill and we saw fire. And we crossed the ocean and pioneered the west, and we took to the sky. The history of man is on a timeline of explorations and this is what's next."
  14. "I want to be a comfort to my friends in tragedy. And I want to be able to celebrate with them in triumph. And in between, I just want to be able to look them in the eye."
  15. "It's going to be an unbearable day."
  16. *singing* "I'm too sexy for my shirt, too sexy for my skirt, too sexy for the other... Things"
  17. "On the off chance that you're not gonna live forever, why not take a shot at being happy now?"
  18. "Let me take a look at you, Don Quixote de La Mancha."
    Suggested by @aniko