One time guest stars only
  1. Rodney Dangerfield as Burns' long lost son
    Welcome to scenic waynesport!
  2. Meryl Streep as Jessica lovejoy
  3. Donald Sutherland as the jebidiah Springfield expert
  4. John Waters as John
    She thought Mindy lived with Mark
  5. Paul Newman as salad dressing
  6. Dave Thomas as Rex Banner
  7. Ernest Borgnine as Ernest Borgnine
  8. Spinal Tap and Spinal Tap
  9. Ludacris and Ludacrest toothpaste
  10. Paul Winfield as Lucious Sweet
    Technically made two appearances. Only exception.
  11. Harvey Fierstein as Karl
  12. Sting as Sting
  13. Darryl Strawberry, Wade Boggs, Ken Griffrey Jr, Ozzie Smith...and the rest...
  14. Michael Carrington as Sideshow Raheem
  15. The Ramones as The Ramones (or the rolling stones)
  16. Kathleen Turner as the creator of Malibu Stacey
  17. Mandy Patinkin as Hugh
  18. Mel Brooks as Mel Brooks
  19. Lawrence Tierney as Don Brodka
    That's right, Don Brodka.
  20. Hank Williams Jr as the canyonero singer
  21. Jeff Goldblum as Troy mcclure's agent
  22. Steven Hawking as Steven Hawking
    More like a frutopia.